"Tridione" in Petit Mal

Tridione compared with malidone in the treatment of petit mal.

Tridione (3,5,5,-trimethyloxazolidine-2 4dione) has been extensively used in the treatment of petit mal for five years, and its success in more than 60% of cases has been well established. Its dangers and limitations are also well recognized (Richards and Everett, 1944; Lennox, 1947). During the past two years 25 men between the ages of 17 and 52 who suffered from frequent petit mal, and 15 of ...

Petit Mal or Pyknolepsy

Epilepsy, Grand Mal, Petit Mal Convulsions

traneous" hormones, (e) metabolic studies, (f) sensitivity of presumed target organ, (g) effects of removal of certain of the endocrines, (h) effect of hypophysectomy on target organs (related to subject "g"), and (i) graft studies. No student of experimental embryology should be denied the opportunity of reading Jost's essay. Finally, the essay by Greep on the interrelations of pituitary funct...

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons.

Low-threshold calcium current (LTCC) in thalamic neurons is important in generation of normal thalamocortical rhythms, and may be involved in the genesis of abnormal activities such as spike-wave discharges that characterize petit mal epilepsy. Ethosuximide and dimethadione, anticonvulsants effective in petit mal, reduced the LTCC when applied to thalamic neurons at clinically relevant concentr...

Differential effects of petit mal anticonvulsants and convulsants

1 Currents evoked by applications of y-aminobutyric acid (GABA) to acutely dissociated thalamic neurones were analysed by voltage-clamp techniques, and the effects of the anticonvulsant succinimides ethosuximide (ES) and a-methyl-a-phenylsuccinimide (MPS) and the convulsants tetramethylsuccinimide (TMS), picrotoxin, pentylenetetrazol (PTZ), and bicuculline methiodide were assessed. 2 TMS (1 juM...